A groundbreaking stem cell treatment developed by Vertex Pharmaceuticals has allowed 10 out of 12 patients with severe type 1 diabetes to stop insulin therapy after one year. While the trial included some side effects and two unrelated deaths, the results mark a major step forward and have progressed to phase 3 clinical testing. ScienceAlert reports: The pancreas's islet cells are responsible for maintaining most of our bodies' insulin levels. Donor transplants of healthy versions of these cells have shown promise in treating type 1 diabetes in the past, but multiple donors are required, and donors are rare. So University of Toronto surgeon Trevor Reichman and colleagues infused 12 patients with islet cells derived from human stem cells in a treatment known as zimislecel. The patients also received immunosuppressive treatment before and after their zimislecel infusion. The islets not only produced insulin inside their bodies, but they did so at safe levels, reducing the patients' dependence on costly doses of insulin. "These findings showed that zimislecel islet cells were functional and self-regulated appropriately," the researchers write in their paper. The mild to moderate side-effects, including decreased kidney function and the anticipated drop in immune cells, were all linked with the immunosuppressive therapy. Sadly, two additional participants died during the trial; one from an infection arising from surgery and the other from complications due to an unrelated condition. As there were no serious adverse events attributed to the new islet cell therapy, the clinical trials are have progressed into phase 3. "These findings provide evidence that pancreatic islets can be effectively produced from pluripotent stem cells and used to treat type 1 diabetes," Reichman and team conclude. The research has been published in the journal NEJM.

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Australia's eSafety Commissioner has urged the government to deny YouTube an exemption from upcoming child safety regulations, citing research showing it exposes more children to harmful content than any other platform. YouTube pushed back, calling the commissioner's stance inconsistent with government data and parental feedback. "The quarrel adds an element of uncertainty to the December rollout of a law being watched by governments and tech leaders around the world as Australia seeks to become the first country to fine social media firms if they fail to block users aged under 16," reports Reuters. From the report: The centre-left Labor government of Anthony Albanese has previously said it would give YouTube a waiver, citing the platform's use for education and health. Other social media companies such as Meta's Facebook and Instagram, Snapchat, and TikTok have argued such an exemption would be unfair. eSafety Commissioner Julie Inman Grant said she wrote to the government last week to say there should be no exemptions when the law takes effect. She added that the regulator's research found 37% of children aged 10 to 15 reported seeing harmful content on YouTube -- the most of any social media site. [...] YouTube, in a blog post, accused Inman Grant of giving inconsistent and contradictory advice, which discounted the government's own research which found 69% of parents considered the video platform suitable for people under 15. "The eSafety commissioner chose to ignore this data, the decision of the Australian Government and other clear evidence from teachers and parents that YouTube is suitable for younger users," wrote Rachel Lord, YouTube's public policy manager for Australia and New Zealand. Inman Grant, asked about surveys supporting a YouTube exemption, said she was more concerned "about the safety of children and that's always going to surpass any concerns I have about politics or being liked or bringing the public onside". A spokesperson for Communications Minister Anika Wells said the minister was considering the online regulator's advice and her "top priority is making sure the draft rules fulfil the objective of the Act and protect children from the harms of social media."

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Intel is shutting down its small automotive division and laying off most of its staff in that group as part of broader cost -cutting efforts to refocus on core businesses like client computing and data centers. Oregon Live reports: "Intel plans to wind down the Intel architecture automotive business," the company told employees Tuesday morning in a message viewed by The Oregonian/OregonLive. The company said it will fulfill existing commitments to customers but will lay off "most" employees working in Intel's automotive group. "As we have said previously, we are refocusing on our core client and data center portfolio to strengthen our product offerings and meet the needs of our customers," Intel said in a written statement to The Oregonian/OregonLive. "As part of this work, we have decided to wind down the automotive business within our client computing group. We are committed to ensuring a smooth transition for our customers." Automotive technology isn't one of Intel's major businesses and the company doesn't report the segment's revenue or employment. But online, the company boasts that 50 million vehicles use Intel processors. Intel says its chips can help enable electric vehicles, provide information to drivers and optimize vehicles' performance. Intel also owns a majority stake in the Israeli company Mobileye, which develops technology for self-driving cars. It doesn't appear the closure of Intel's automotive group will directly affect Mobileye's operations.

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An anonymous reader quotes a report from Ars Technica: After 20 years, being able to look at any corner of the planet in Google Earth doesn't seem that impressive, but it was a revolution in 2005. Google Earth has gone through a lot of changes in that time, and Google has some more lined up for the service's 20th anniversary. Soon, Google Earth will help you travel back in time with historic Street View integration, and pro users will get some new "AI-driven insights" -- of course Google can't update a product without adding at least a little AI. [...] While this part isn't new, Google is also using the 20th anniversary as an opportunity to surface its 3D timelapse feature. These animations use satellite data to show how an area has changed from a higher vantage point. They're just as cool as when they were announced in 2021. The AI layers are launching in the coming weeks in Google Earth web and mobile as part of Google's Professional Advanced offering. If you use that version of Earth, you should have access to a collection of so-called "AI-driven insights." For instance, you can find the average surface temperature or tree canopy coverage in a given area. This could be of help in urban planning or construction, but it's unclear how many of these insights the app will have. Google says the AI angle here is that the new layers use machine learning to categorize pixels. It's possible Google has just reached the "AI as a buzzword" stage.

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Health and Human Services Secretary Robert F. Kennedy Jr. announced a major federal campaign to promote wearable health tech, aiming for every American to adopt a device within four years as part of a broader effort to "Make America Healthy Again." Gizmodo reports: RFK Jr. announced the initiative Tuesday afternoon during a House Energy and Commerce Health Subcommittee meeting to discuss the HHS' budget request for the upcoming fiscal year. In response to a question from representative Troy Balderson (R-Ohio) about wearables, Kennedy revealed that HHS will soon conduct one of the agency's largest ever advertising campaigns to promote their use. He added that in his ideal future, every American will be donning a wearable within the next four years. "It's a key part of our mission to Make America Healthy Again," RFK Jr. stated in an X post following the question.

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alternative_right shares a report from Phys.Org: In new research published by scientists studying fission yeastâ"a single-celled organism surprisingly similar to human cellsâ"researchers found that caffeine affects aging by tapping into an ancient cellular energy system. A few years ago, the same research team found that caffeine helps cells live longer by acting on a growth regulator called TOR (target of rapamycin). TOR is a biological switch that tells cells when to grow, based on how much food and energy is available. This switch has been controlling energy and stress responses in living things for over 500 million years. But in their latest study, the scientists made a surprising discovery: Caffeine doesn't act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans. "When your cells are low on energy, AMPK kicks in to help them cope," explains Dr. Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study's senior author. "And our results show that caffeine helps flip that switch." Interestingly, AMPK is also the target of metformin, a common diabetes drug that's being studied for its potential to extend human lifespan together with rapamycin. Using their yeast model, the researchers showed that caffeine's effect on AMPK influences how cells grow, repair their DNA, and respond to stress -- all of which are tied to aging and disease. The study has been published in the journal Microbial Cell.

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Where did you GOTO on your vacation? Nowhere. GOTO is considered harmful. Original --Remy

Everybody knows that you should never use "goto" statements. Well, except in one or two rare circumstances that you won't come across anyway. But even when you do come across those situations, they're usually "mirage cases" where there's no need to "goto" anyway. Kinda like today's example, written by Jonathan Rockway's colleague. Of course, the irony here is that the author likely tried to use "continue" as his label, but was forced to abbreviate it to "cont" in order to skirt compiler "reserved words" errors.

while( sysmgr->getProcessCount() != 0 ) { // Yes, I realize "goto" statements are considered harmful, // but this is a case where it is OK to use them cont: //inactivation is not guaranteed and may take up to 3 calls sysmgr->CurrentProcess()->TryInactivate(); if( sysmgr->CurrentProcess()->IsActive() ) { Sleep(DEFAULT_TIMEOUT); goto cont; } /* ED: Snip */ //disconnect child processes if( sysmgr->CurrentProcess()->HasChildProcesses() ) { /* ED: Snip */ } /* ED: Snip */ if( sysmgr->CurrentProcess()->IsReusable() ) { sysmgr->ReuseCurrentProcess(); goto cont; } sysmgr->CloseCurrentProcess(); }

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An anonymous reader quotes a report from 404 Media: A massive data center for Meta's AI will likely lead to rate hikes for Louisiana customers, but Meta wants to keep the details under wraps. Holly Ridge is a rural community bisected by US Highway 80, gridded with farmland, with a big creek -- it is literally named Big Creek -- running through it. It is home to rice and grain mills and an elementary school and a few houses. Soon, it will also be home to Meta's massive, 4 million square foot AI data center hosting thousands of perpetually humming servers that require billions of watts of energy to power. And that energy-guzzling infrastructure will be partially paid for by Louisiana residents. The plan is part of what Meta CEO Mark Zuckerberg said would be "a defining year for AI." On Threads, Zuckerberg boasted that his company was "building a 2GW+ datacenter that is so large it would cover a significant part of Manhattan," posting a map of Manhattan along with the data center overlaid. Zuckerberg went on to say that over the coming years, AI "will drive our core products and business, unlock historic innovation, and extend American technology leadership. Let's go build! " What Zuckerberg did not mention is that "Let's go build" refers not only to the massive data center but also three new Meta-subsidized, gas power plants and a transmission line to fuel it serviced by Entergy Louisiana, the region's energy monopoly. Key details about Meta's investments with the data center remain vague, and Meta's contracts with Entergy are largely cloaked from public scrutiny. But what is known is the $10 billion data center has been positioned as an enormous economic boon for the area -- one that politicians bent over backward to facilitate -- and Meta said it will invest $200 million into "local roads and water infrastructure." A January report from NOLA.com said that the the state had rewritten zoning laws, promised to change a law so that it no longer had to put state property up for public bidding, and rewrote what was supposed to be a tax incentive for broadband internet meant to bridge the digital divide so that it was only an incentive for data centers, all with the goal of luring in Meta. But Entergy Louisiana's residential customers, who live in one of the poorest regions of the state, will see their utility bills increase to pay for Meta's energy infrastructure, according to Entergy's application. Entergy estimates that amount will be small and will only cover a transmission line, but advocates for energy affordability say the costs could balloon depending on whether Meta agrees to finish paying for its three gas plants 15 years from now. The short-term rate increases will be debated in a public hearing before state regulators that has not yet been scheduled. The Alliance for Affordable Energy called it a "black hole of energy use," and said "to give perspective on how much electricity the Meta project will use: Meta's energy needs are roughly 2.3x the power needs of Orleans Parish ... it's like building the power impact of a large city overnight in the middle of nowhere."

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The Register's Simon Sharwood reports: Huawei's chairman Xu Zhijun -- aka Eric Xu -- has called out China's enormous lead in fiber-to-the-room (FTTR) installations. Speaking at last week's Mobile World Congress event in Shanghai, Xu shared his views on the telecommunications industry's future growth opportunities and said by the end of 2025 China will be home to 75 million FTTR installations -- but just 500,000 exist outside the Middle Kingdom. Xu said FTTR will benefit businesses by increasing their internet connection speeds, helping them address spotty Wi-Fi coverage, allowing them to deploy tech in more places, and therefore creating more opportunities to adopt productivity-boosting devices and services. FTTR will also help carriers to sell more expensive packages, he said. Xu also urged telecom carriers to target high-growth user groups like delivery riders and livestream influencers, citing their above-average data consumption and revenue potential. Delivery riders, who will make up 5% of the global workforce by 2030, use four times more voice minutes and double the data of average users, while influencers generate five times the data usage and four times the revenue. He also pushed for greater collaboration between carriers and platforms to deliver more high-res video content, and called for improved efficiency in networking equipment and device power use. "Xu said Huawei is here to help carriers deliver any of the scenarios he mentioned," concludes Sharwood. "And of course it is, because the Chinese giant has a thriving business selling to telcos -- or at least to telcos beyond the liberal democracies that have largely decided Huawei's close ties with Beijing mean the company and its products represent an unacceptable threat to the operation of critical infrastructure."

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Longtime Slashdot reader williamyf writes: Firefox 140 just landed. Some user-facing features include: Vertical Tabs: You can now keep more -- or fewer -- pinned tabs in view for quicker access to important windows. Just drag the divider to resize your pinned tabs section. Unload Tabs: You can now unload tabs by right-clicking on a tab (or multiple selected tabs) and selecting "Unload Tab." This can speed up performance by reducing Firefox's memory and CPU usage. But the most important feature? This release is an Extended Support Release (ESR). Why are ESRs so important? ESR is the Firefox version that ships as the default with many Linux distributions. Some downstream projects (like Waterfox) depend on the ESR version. Many enterprise software systems are tested only against ESR. When features are dropped -- like support for older operating systems or Flash -- ESR keeps that functionality around for longer. And speaking of old operating systems: If you are using Windows 7, 8.1, or macOS 10.12~10.15, note that FireFox ESR 115 (the last version supporting these OSs) will continue to receive patches until at least September 2025. So one can see why ESR is very important for some people. The release notes are available here.

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Google DeepMind has launched Gemini Robotics On-Device, a new language model that enables robots to perform complex tasks locally without internet connectivity. TechCrunch reports: Building on the company's previous Gemini Robotics model that was released in March, Gemini Robotics On-Device can control a robot's movements. Developers can control and fine-tune the model to suit various needs using natural language prompts. In benchmarks, Google claims the model performs at a level close to the cloud-based Gemini Robotics model. The company says it outperforms other on-device models in general benchmarks, though it didn't name those models. In a demo, the company showed robots running this local model doing things like unzipping bags and folding clothes. Google says that while the model was trained for ALOHA robots, it later adapted it to work on a bi-arm Franka FR3 robot and the Apollo humanoid robot by Apptronik. Google claims the bi-arm Franka FR3 was successful in tackling scenarios and objects it hadn't "seen" before, like doing assembly on an industrial belt. Google DeepMind is also releasing a Gemini Robotics SDK. The company said developers can show robots 50 to 100 demonstrations of tasks to train them on new tasks using these models on the MuJoCo physics simulator.

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An anonymous reader quotes a report from The Verge: Microsoft is planning to cut jobs in the company's Xbox gaming business, as early as next week. I first reported in Notepad earlier this month that Microsoft was planning Xbox layoffs "potentially by the end of the month," and now Bloomberg says a round of "major layoffs" is due next week. I understand managers at Microsoft have been briefed about Xbox cuts and wider layoffs in other parts of Microsoft's businesses. The upcoming cuts are also expected to hit Microsoft's sales organization, just at the start of a new financial year. Microsoft is planning to restructure parts of its Xbox business as it looks ahead to its next generation of consoles. One source tells me Microsoft is restructuring Xbox distribution across central Europe, resulting in some Xbox operations ceasing in some regions. The expected layoffs will be in addition to the 6,000 cuts Microsoft already made in May, and on top of the more than 300 job cuts earlier this month.

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Waymo and Uber have launched a robotaxi service in Atlanta, allowing users to book autonomous rides through the Uber app across a 65-square-mile area. They will not yet travel on highways or to the airport. CNBC reports: The vehicles feature Waymo's driverless technology, known as the Waymo Driver, integrated into battery electric Jaguar I-PACE SUVs. [...] In Atlanta and Austin, Waymo rides are only available through Uber's app, while in San Francisco and Los Angeles, passengers book through the Waymo One app. Waymo said it would start with dozens of robotaxis live in Atlanta. The company says it currently has more than 1,500 autonomous vehicles in its U.S. fleet. The Waymo-Uber partnership only covers passenger rides, not Uber Eats deliveries.

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Microsoft has released a modern, open-source version of its classic MS-DOS Editor -- built with Rust and compatible with Windows, macOS, and Linux. It's now simple called "Edit." Ars Technica reports: Aside from ease of use, Microsoft's main reason for creating the new version of Edit stems from a peculiar gap in modern Windows. "What motivated us to build Edit was the need for a default CLI text editor in 64-bit versions of Windows," writes [Christopher Nguyen, a product manager on Microsoft's Windows Terminal team] while referring to the command-line interface, or CLI. "32-bit versions of Windows ship with the MS-DOS editor, but 64-bit versions do not have a CLI editor installed inbox." [...] Linux users can download Edit from the project's GitHub releases page or install it through an unofficial snap package. Oh, and if you're a fan of the vintage editor and crave a 16-bit text-mode for your retro machine that actually runs MS-DOS, you can download a copy on the Internet Archive. [...] At 250KB, the new Edit maintains the lightweight philosophy of its predecessor while adding features the original couldn't dream of: Unicode support, regular expressions, and the ability to handle gigabyte-sized files. The original editor was limited to files smaller than 300KB depending on available conventional memory -- a constraint that seems quaint in an era of terabyte storage. But the web publication OMG! Ubuntu found that the modern Edit not only "works great on Ubuntu" but noted its speed when handling gigabyte-sized documents.

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An anonymous reader quotes a report from Transport Topics: A ship that caught fire in the Pacific Ocean earlier this month has sunk. The vessel was abandoned in the middle of the pacific -- about 360 miles from land -- after a blaze. It was carrying about 3,000 vehicles of which about 800 were EVs. Damage caused by the fire was compounded by heavy weather, causing the ship to take on water and ultimately sink on June 23, the vessel's manager, Zodiac Maritime, said in a statement on June 24. Smoke was initially seen emanating from a deck carrying electric vehicles, Zodiac said when the incident first happened. While the ship's relative distance from land means that it will sink into ocean that is approximately 5,000 meters deep, it also made a rapid response trickier. The second of three specialist vessels that were due to assist the ship arrived on June 15, more than a week after the fire first broke out. The vessel was carrying cars from a range of manufacturers including Chery Automobile Co. and Great Wall Motor Co. to Mexico, people familiar with the matter said at the time.

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More than 110 million people across Europe suffer high levels of health-damaging noise pollution, according to a report. The resulting physiological stress and sleep disturbance leads to 66,000 early deaths a year and many cases of heart disease, diabetes and depression. The Guardian: The report, from the European Environment Agency (EEA), focuses on noise from cars, trains and aeroplanes and found that 20% of the population of the European Economic Area (EEA) were affected. Separate research, using a slightly lower threshold for dangerous noise pollution, found that 40% of the UK population were exposed to harmful transport noise. Seventeen million people endure particularly high noise pollution -- "long-term, high-annoyance" -- and almost 5 million suffer "severe" sleep disturbance. Fifteen million children live in areas of harmful noise. The harm to health from noise is greater than that from higher-profile risks including secondhand tobacco smoke or lead exposure, and incurs an economic cost of almost $116bn a year, the analysis found. The damage to health is likely to be an underestimate, the researchers said. Using the World Health Organization's stricter threshold for risky noise pollution gives an estimate of 150 million people across Europe exposed. The EU's target to cut the number of people chronically disturbed by transport noise by 30% by 2030 will not be met without further action, the researchers said.

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Google has begun rolling out a feature that allows Chrome users on Android to move the browser's address bar to the bottom of the screen. This capability has been available to iOS Chrome users since 2023 and aims to improve accessibility for users with larger devices. Users can relocate the address bar by pressing and holding on it and selecting the move option, or by adjusting the setting through Chrome's settings menu. The feature addresses usability concerns for users of phones with bigger screens, where reaching the top of the display can prove difficult during one-handed operation.

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Western Digital has succeeded in having the sum it owed from a patent infringement case reduced from $553 million down to just $1 in post-trial motions, when the judge found the plaintiff's claims had shifted during the course of the litigation. From a report: The storage biz was held by a California jury to have infringed on data encryption patents owned by SPEX Technologies Inc in October, relating to several of its self-encrypting hard drive products. WD was initially told to pay $316 million in damages, but District Judge James Selna ruled the company owed a further $237 million in interest charges earlier this year, bringing the total to more than half a billion dollars. In February, WD was given a week to file a bond or stump up the entire damages payment. Selna granted Western Digital's post-trial motion to reduce damages, writing that "SPEX's damages theory changed as certain evidence and theories became unavailable" and there was "insufficient evidence from which the Court could determine a reasonable royalty."

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An anonymous reader shares a report: Apple customers aren't thrilled they're getting an ad from the Apple Wallet app promoting the tech giant's Original Film, "F1 the Movie." Across social media, iPhone owners are complaining that their Wallet app sent out a push notification offering a $10 discount at Fandango for anyone buying two or more tickets to the film. The feature film, starring Brad Pitt, explores the world of Formula 1 and was shot at actual Grand Prix races. It also showcases the use of Apple technology, from the custom-made cameras made of iPhone parts used to film inside the cars, to the AirPods Max that Pitt's character, F1 driver Sonny Hayes, sleeps in. However well-received the film may be, iPhone users don't necessarily want their built-in utilities, like their digital wallet, marketing to them.

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Philips Hue will raise prices across its smart lighting and security products for US customers starting July 1st, with parent company Signify attributing the increases directly to tariffs. The company initially notified customers that prices would "go up" through a promotional message before confirming the tariff-related reasoning in a statement. Signify has not provided specific pricing details or identified which products will be affected, though the company's statement suggests changes may impact the entire Hue lineup. Some products already reflect higher US pricing, including the new $219.99 Hue Play Wall Washer light, which costs approximately 10% more than the European price when currencies are converted. The latest $32.99 Smart Button also exceeds the $24.99 launch price of its predecessor, while European pricing remained at 21.99 euro ($25.50) for both generations.

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